However, the precise mechanism remains elusive and it is unclear which structures are involved. Given that brain structure and function are highly related, identification of anatomical differences may shed light upon the mechanism of tinnitus generation and maintenance. As this area of research is expanding, we identify some key considerations for research design and propose strategies for future research. Despite the significant unmet clinical need for a safe and effective drug targeting tinnitus relief, there is currently not a single FDA-approved drug on the market. Even further, some drugs are used based on known underlying neuronal changes thought to be a neural correlate of tinnitus. Although a detailed understanding of the pathophysiology and etiology of CNS disorders remains elusive, the last decade has witnessed a huge leap in our understanding of the basic biological processes that contribute to many human disorders. The affective and cognitive deficits underlying these behaviours have been linked to abnormalities in functional interhemispheric connectivity. Our results suggest that structural brain alterations affect neural networks for sexual processing by way of disrupted functional connectivity, which may entail abnormal sexual arousal patterns. The aims of this research are to classify the types of breast abnormalities using artificial neural network (ANN) classifier and to evaluate the accuracy performance using receiver operating characteristics (ROC) curve. Aberrant sensory processing plays a fundamental role in the pathophysiology of dystonia; however, its underpinning neural mechanisms in relation to dystonia phenotype and genotype remain unclear.
Transcranial direct current stimulation (tDCS) is a neuromodulation technique that has been increasingly used over the past decade in the treatment of neurological and psychiatric disorders such as stroke and depression. The neural circuits underlying behavior during the AST are highly conserved across humans, nonhuman primates and rodents, providing excellent face, construct and predictive validity. A verb generation task and its two controls (noun and verb reading) were also investigated. The central auditory system has a crucial role in tinnitus generation and maintenance. It is now clear that tinnitus is generated in the brain, not in the ear, and that it is correlated with pathologically altered spontaneous activity of neurons in the central auditory system. Both increased spontaneous firing rates and increased neuronal synchrony have been identified as putative neuronal correlates of phantom sounds in animal models, and both phenomena can be triggered by damage to the cochlea. Various mechanisms could underlie the generation of such aberrant activity. We also assess the limits of their explanatory power, thus demonstrating where an understanding is still lacking and where further research may be needed.
Neural Mechanisms Underlying Perilesional Transcranial Direct Current Stimulation in Aphasia: A Feasibility Study. Neuromodulation; Temporoparietal area; Tinnitus; Transcranial direct current stimulation; Treatment; tDCS PMID: 26498289 PubMed as supplied by publisher Similar articles Icon for Springer Select item 26494801 9. Aberrant spontaneous brain activity in chronic tinnitus patients revealed by resting-state functional MRI. This idea has been investigated for many years through a large number of animal and human studies, but evidence remains fragmented. Both sleep states appear to be important for neuronal development, but the corresponding contribution is likely to be different. This paper reviews four decades of economics research on the brain drain, with a focus on recent contributions and on development issues.