Patients on loop diuretics are more susceptible to noise-induced hearing loss than they would otherwise be. Other diuretics can also be ototoxic such as some of the thiazide diuretics. Drug-induced damage to these structures of the auditory and balance system can result in hearing loss, tinnitus, and dysequilibrium or dizziness. Hearing loss can be temporary but is usually irreversible with most agents. For patient education resources, see the Ear, Nose, and Throat Center, as well as Hearing Loss. Beck: My recollection is that patients taking loop diuretics are more susceptible to noise induced hearing loss than they would otherwise be?
In addition, there are more than 200 medications that can adversely affect hearing. In addition, the susceptibility of noise-induced hearing loss between individuals varies as much as 30 to 50 dB, possibly due to differences in ear anatomy and physiology, prior exposure to noise, and interactions of medications 19. Furthermore, coadministration of loop diuretics and aminoglycoside antibiotics may have a synergistic effect on ototoxic hearing loss 56. Patients may not notice ototoxic hearing loss until a communication problem becomes apparent, signifying that hearing loss within the frequency range important for understanding speech has already occurred. Hearing loss can be categorised as mild, moderate, severe, or profound. Noise-induced hearing loss (NIHL) typically manifests as elevated hearing thresholds (i.e. This includes loop diuretics such as furosemide and bumetanide, non-steroidal anti-inflammatory drugs (NSAIDs) both over-the-counter (aspirin, ibuprofin, naproxin) as well as prescription (celecoxib, diclofenac, etc. The most common tinnitus is constant, high-pitched ringing or static-like sound. I have not seen a study on the relationship of treating atherosclerosis and reducing risk of hearing loss, but it makes sense to me that having a healthier heart and blood vessels and reduced risk of blood clots would then reduce risk of this type of hearing loss.
Sensorineural hearing loss (SNHL) is one of the most common clinical disorders, and is associated with a multitude of etiologies. The patient’s history of exposure to noise, occupational and otherwise, should be specifically addressed. It is clear, however, that MRI with gadolinium is much more sensitive than ABR for diagnosis of small lesions. This applies to most drugs for high blood pressure, cholesterol lowering drugs (statins), drugs given for anxiety and most antidepressants. They may then blame the drug even though it is blameless. This damage can cause hearing loss and a small number of the affected people develop tinnitus as a consequence of this hearing loss. Diuretics Some other drugs which are occasionally ototoxic are a group of drugs called loop diuretics which are used to increase the production of urine in the treatment of high blood pressure, heart failure and some kidney disorders. ‘Ototoxicity induced by furosemide. The ability of drugs to reduce noise induced hearing loss (NIHL) has been evaluated in diverse experimental conditions (animal species, noise intensities, durations, assessment techniques, etc), making it difficult to assess their relative efficacy. Methods: The drugs studied included furosemide (loop diuretic) and the antioxidants N Acetyl-L-Cysteine, vitamins A, C, E with the vasodilator magnesium. The present experiment was designed to overcome these obstacles by enabling a more uniform comparison of several of the drugs found to provide protection from NIHL, and also to gain insight into the mechanism of NIHL. They had normal hearing, defined as ABR thresholds to broadband clicks of 65 dB peak equivalent (pe) SPL or better.
Hearing Health And Care: The Need For Improved Hearing Loss Prevention And Hearing Conservation Practices
More than half of childhood hearing impairment is thought to be hereditary; Susceptibility to noise-induced hearing loss may also be genetically determined. These protectant combinations can be administered prior to, simultaneously with, or subsequently to exposure to noise other toxic insults. The combination of claim 1 comprising a combination of two of said protectant agents other than glutathione. 5. A method for treating sudden hearing loss in a patient comprising administering to said patient an effective amount of a protectant agent comprising a methionine protectant agent, said methionine protectant agent corresponding to Formula 1. These combinations include complementary agents that by various mechanisms produce the prophylactic and/or therapeutic effects of neuroprotection and preventing or ameliorating both temporary and permanent noise induced hearing loss. Jointly, the two sides of hearing loss can wreak havoc on a person’s quality of life, as the physical reality creates the loss and the psychological reality prevents people from treating it. More people could benefit from a hearing aid than in fact wear one. Tinnitus is commonly accompanied by hearing loss, and roughly 90 of persons with chronic tinnitus have some form of hearing loss (Davis and Rafaie, 2000; Lockwood et al, 2002). Most patients with noise trauma describe a whistling tinnitus (Nicholas-Puel et al,. Somatic tinnitus — tinnitus from the neck (cervical tinnitus) or jaw/TMJ related tinnitus. Hearing loss is the most common form of sensory impairment in humans and affects more than 40 million people in the United States alone. Over recent years, more than 100 genetic loci have been linked to hearing loss and many of the affected genes have been identified. Table 2: Genetic susceptibility and noise-induced hearing loss. Use of ototoxic medication was counted when participants reported medications of aminoglycoside, loop diuretics, antineoplastic drugs or non-steroidal anti-inflammatory drugs (missing for five participants). Patient consent: Obtained.
Sensorineural Hearing Loss In Adults
Otoacoustic emissions (OAEs) are sounds of cochlear origin, which can be recorded by a microphone fitted into the ear canal. As part of the audiological diagnostic test battery, OAEs can contribute to differential audiological diagnosis, they can be used to monitor the effects of treatment and they can be helpful in the selection of hearing aids and of surgical options. OAEs’ sound pressure below 3 kHz, as otherwise drum vibrations would simply move air in and out of the ear canal. Hearing will be more sensitive and cochlear frequency resolution (and selectivity) will be more acute in a cochlea with less damping. This Clinical Practice Guideline addresses questions related to changes in hearing profile category and asymmetry. Sensorineural hearing loss (SNHL) is the most common type of HL in the general population and is usually related to long-term exposure to noise. 3 Risk factors include cumulative drug dose, duration of treatment, bacteraemia, renal or liver failure, and concomitant administration of drugs such as loop diuretics, that have a synergistic ototoxic effect. This study was divided into 2 parts of which the first relates to prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene in a cohort of MDR-TB patients.5,6 Although these data have been published, they are cited where referred to in the text for completeness. Age, gender, history of noise exposure, specific aminoglycoside therapy, presence of tinnitus, HIV status and whether patients were on combination antiretroviral therapy (cART) were recorded.